lymphocytes

[Developmental Cell] Researchers observed unexpectedly high levels of hepatocyte heterogeneity in the developing liver and the progressive construction of the zonated metabolic functions from pericentral to periportal hepatocytes, which was orchestrated with the development of sinusoid endothelial, stellate, and Kupffer cells.

[EMBO Journal] Single-cell transcriptomics of LAT-deficient double-negative third stage γδint cells demonstrated no sign of commitment to the γδ T-cell lineage, apart from γδ T cell receptor expression.

[Cancer Research] Researchers showed in Pax5+/- mice that transient, early-life administration of clinically relevant doses of ruxolitinib, a JAK1/2 inhibitor, significantly mitigated the risk of B cell acute lymphoblastic leukemia following exposure to infection.

[Lancet Haematology] Scientists reported the results of a prospective, single-arm, Phase II clinical trial done at the University Medical Center Utrecht and the Princess Máxima Center for Pediatric Oncology to investigate individualized dosing of anti-thymocyte globulin for unrelated allogeneic HSC transplantation in pediatric patients.

[Cell Reports] Using single-cell sequencing, scientists showed that tumor-induced lymphocytes include skewed T cell clonotypes, which were characterized by exhaustion or nonexhaustion signatures.

[Trends in Parasitology] Understanding that antibodies play central roles in malaria immunity and systemic lupus erythematosus, the authors discuss how autoreactive B cells contribute to malaria immunity but promote SLE pathology in the absence of malaria.