lymphocytes

[Nature Communications] Prediction identified genes and pathways known to be associated with anti-PD1, and was further validated by six CRISPR gene sets associated with tumor resistance to cytotoxic T cells and targets of the 36 compounds that had been tested in clinical trials for combination treatments with anti-PD1.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists reported that NRP-1, encoding transmembrane protein neuropilin-1, was highly expressed in macrophages and dendritic cells but not CD4+ T cells, serving as an anti-HIV factor to inhibit the infectivity of HIV-1 progeny virions.

[Nature Communications] Investigators showed the administration of allogeneic human peripheral blood natural killer cells delays viral rebound following interruption of anti-retroviral therapy in humanized mice infected with HIV-1.

[Nature Microbiology] Researchers compared SARS-CoV-2-specific antibody and T cell responses between older adults and a younger control group after receiving two doses of BNT162b2.

[Frontiers in Immunology] According to large-scale single-cell analysis, recovered patients, who had severe symptoms, still exhibited peripheral immune disorders one-two months after symptom onset.

[Oncoimmunology] The authors investigated the efficacy of CD29- and CD44-targeted NIR-PIT (CD29-PIT and CD44-PIT, respectively) in the B16 melanoma model, which was highly pigmented.