lymphoid cells

[npj Breast Cancer] The authors discuss the biological understanding of tumor-infiltrating lymphocytes (TILs), their analytical and clinical validity and efforts towards the clinical utility in breast cancer, and the current status of programmed death-ligand 1and TIL testing across different continents.

[Breast Cancer Research and Treatment] Breast cancer is immunogenic and a variety of vaccines have been designed to boost immunity directed against the disease. Newer approaches are designing vaccines to prevent breast cancer by intercepting high-risk lesions such as ductal carcinoma in situ to limit the progression of these tumors to invasive cancer.

[Human Immunology] The authors reviewed the molecular mechanisms and the role of immune cells and responses involved in pulmonary hypertension development.

[Signal Transduction and Targeted Therapy] The authors showed that natural killer (NK)-derived exosomes from lean mice attenuated obesity-induced insulin resistance and inflammation in mice of type 2 diabetes, and that lean NK-derived exosomes enhanced insulin sensitivity and relieve inflammation in adipocytes and hepatocytes.

[Proceedings of the National Academy of Sciences of the United States of America] Using exome sequencing, RNA-sequencing, and functional immunologic studies, scientists characterized 28 normal karyotype (NK)-AML patients with over 5 year first remissions after chemotherapy and compared them to a well-matched group of 31 NK-AML patients who relapsed within two years.

[Haematologica] PVRIG blockade significantly enhanced NK-cell killing of poliovirus receptor-related 2 (PVRL2)+, poliovirus receptorlo AML cell lines, and significantly increased NK-cell activation and degranulation in the context of patient primary AML blasts.