lymphoid cells

[Cancer Gene Therapy] In the MC38 tumor model, combined administration of plasmids encoding IL-12 and an anti-PD-1 antibody induced significant anti-tumor responses, yet similar to the monotherapies.

[Journal of Translational Medicine] Researchers created a CAR-T that united in one product the two modalities: a CRISPR interference- circuit prevents programmed cell death protein 1 expression upon antigen-encounter.

[PLoS Neglected Tropical Diseases] Scientists investigated the expression of FOXP3+ Treg cells in leprosy skin lesions and to correlate their clinical forms, laboratory characteristics, and the immune reconstitution syndrome in HIV-leprosy co-infection.

[Journal of Neuroinflammation] There is increasing evidence that dendritic cells (DCs) are implicated as key modulators in keeping the balance between immune response and tolerance in the central nervous system.

[Haematologica] The authors showed that, unlike normal B cells, diffuse large B cell lymphoma (DLBCL) cells express abundant levels of transducin b-like protein 1 and its overexpression correlates with poor clinical outcome regardless of DLBCL molecular subtype.

[Nature Communications] Investigators indicated that 5′-Azacitidine increased the immunogenicity of acute myeloid leukemia cells, enhancing recognition and elimination of malignant cells by highly efficient CTLA-4negative anti-CD123 chimeric antigen receptor (CAR) T cells.