lymphoid cells

[Nature Biomedical Engineering] Researchers reported a high-throughput screen based on the functional interaction of mouse- or patient-derived breast tumour organoids and tumor-specific cytotoxic T cells for the identification of epigenetic inhibitors that promote antigen presentation and potentiate T cell-mediated cytotoxicity.

[Cell Reports] Investigators analyzed over two million cells from 16 pancreata obtained from donors with type 2 diabetes and 13 pancreata from age-similar non-diabetic controls.

[International Journal of Cardiology] Researchers revealed that programmed cell death 5 (Pdcd5) deficiency attenuated cardiac aging by reducing cellular senescence and apoptosis, and increasing Parkin-mediated mitophagy, likely through p53.

[Molecular Therapy-Methods & Clinical Development] Scientists retrospectively analyzed 143 patients treated with CART19 to evaluate the effect of peripheral leukemia burden at time of apheresis.

[Molecular Therapy-Methods & Clinical Development] Cell-free DNA isolated from 74 blood samples of 12 patients during lymphoma treatment with the anti-CD19 CAR-T cell product axicabtagene ciloleucel were analyzed.

[Drug Discovery Today] Scientists provide a concise overview of the main principles and potential of cell tracking, followed by a discussion of the clinically relevant labeling strategies and their application in adoptive T cell therapies (ACT).