lymphoid cells

[Science Advances] The authors quantified preproinsulin-specific CD8+ T cells within different areas of the human pancreas from nondiabetic controls, autoantibody-positive donors, and donors with type 1 diabetes to investigate their role in diabetes development.

[Scientific Reports] Intraperitoneal injection of lipopolysaccharide and oral gavage of ampicillin increased IFN-γ and TNF-α expression in the spleen, colon, and hippocampus, while IL-10 expression decreased.

[Nature Reviews Immunology] An important challenge during the COVID-19 pandemic has been to understand asymptomatic disease and the extent to which this may be a source of transmission. Areas that need greater clarity include the extent to which asymptomatic disease leads to persistent symptoms, and the quality, quantity and durability of immune priming required to confer subsequent protection.

[Nature Communications] Hypothesizing that EGFR mutations alter tumor-immune interactions, scientists compared tumor-infiltrating lymphocytes between EGFR mutant and wild type tumors through single-cell transcriptomic analysis.

[Oncogene] To identify clinically relevant microenvironmental and cancer features, scientists applied single-cell RNA sequencing to ten human lung adenocarcinomas and ten normal control tissues.

[Molecular Therapy-Oncolytics] CAR-engineered natural killer (NK)-92 cells have demonstrated robust antitumor activity in in vitro and in vivo preclinical studies, propelling the clinical development of CAR NK-92 cells.