The Immunology of Asymptomatic SARS-CoV-2 Infection: What Are the Key Questions?

An important challenge during the COVID-19 pandemic has been to understand asymptomatic disease and the extent to which this may be a source of transmission. Areas that need greater clarity include the extent to which asymptomatic disease leads to persistent symptoms, and the quality, quantity and durability of immune priming required to confer subsequent protection.