lymphoid cells

[Surface Oncology] Surface Oncology, a clinical-stage immuno-oncology company developing next-generation immunotherapies that target the tumor microenvironment, announced the first patient has been dosed by GlaxoSmithKline in the Phase I study of GSK4381562 in patients with solid tumors.

[Scientific Reports] The authors investigated the features of CCR8+ Tregs in lung cancer patients. CCR8+ Tregs were highly activated and infiltration of CCR8+ Tregs in tumors was associated with poor prognosis in lung cancer patients.

[PLoS Pathogens] In both model systems, Mycobacterium tuberculosis (Mtb)-infected mice were resistant to the pathological consequences of secondary SARS-CoV-2 infection, and SARS-CoV-2 infection did not affect Mtb burdens.

[Journal of Immunology] Scientists showed that, in comparison with a pre-epidemic isolate infection of Zika virus (ZIKV), CD4 T cells were less polarized to the Th1 subtype following Brazilian ZIKV isolate challenge in mice.

[Journal of Experimental Medicine] Genetic fate-mapping analysis revealed that liver Ly49E+ ILC1s with strong cytotoxicity originated from embryonic non–bone marrow hematopoietic progenitor cells, persisted locally during postnatal life, and mediated protective immunity against cytomegalovirus infection in newborn mice.

[Frontiers in Immunology] Scientists examine the immunosuppressive features of the leukemia microenvironment, discuss how preclinical modeling help predict adoptive cell therapy (ACT) associated toxicities and dysfunction, and explore publications that have employed syngeneic modeling in ACT studies for the improvement of therapy for leukemias.