lymphoid cells

[JCI Insight] To rescue T and NK cells after UCART7, researchers created hematopoietic stem cells (HSCs) genetically deleted for CD7. CD7-KO HSCs were able to engraft immunodeficient mice and differentiate into T and NK cells lacking CD7 expression.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators analyzed RNA-sequencing data of 321 primary T-cell acute lymphoblastic leukemias (T-ALLs), 20 T-ALL cell lines, and 25 normal human tissues, revealing that TET2 was transcriptionally repressed or silenced in 71% and 17% of T-ALL, respectively.

[Nature Communications] Researchers showed that Tet2 regulated pathologic interactions between β cells and immune cells and controlled damaging inflammatory pathways.

[Immunity Inflammation and Disease] Graft-versus-host disease (GVHD) was induced in lethally irradiated BALB/c mice. M2 macrophages derived from donor bone marrow (BM) were administered intravenously, while controls received donor BM-mononuclear cells and splenocytes.

[Gut] Blood and tumors were analyzed from Intrahepatic cholangiocarcinomapatients (iCCA) and controls. Treatment and correlative studies were performed in mice with autochthonous and established orthotopic iCCA tumors treated with anti-granulocyte-macrophage colony-stimulating factor (GM-CSF) monoclonal antibody.

[Acta Neuropathologica Communications] In mouse models, investigators assessed whether dextran sodium sulfate-mediated colitis could exert lingering effects on dopaminergic pathways in the brain and whether colitis increased vulnerability to a subsequent exposure to the dopaminergic neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.