CD7-Deleted Hematopoietic Stem Cells Can Restore Immunity after CAR T Cell Therapy

By
Justin.choi
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To rescue T and NK cells after UCART7, researchers created hematopoietic stem cells (HSCs) genetically deleted for CD7. CD7-KO HSCs were able to engraft immunodeficient mice and differentiate into T and NK cells lacking CD7 expression.
[JCI Insight]
Kim, M. Y., Cooper, M. L., Jacobs, M. T., Ritchey, J. K., Hollaway, J., Fehniger, T. A., & DiPersio, J. F. (2021). CD7-deleted hematopoietic stem cells can restore immunity after CAR T cell therapy. JCI Insight, 6(16). https://doi.org/10.1172/jci.insight.149819 Cite
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