Experimental Colitis Promotes Sustained, Sex-Dependent, T-Cell-Associated Neuroinflammation and Parkinsonian Neuropathology

In mouse models, investigators assessed whether dextran sodium sulfate-mediated colitis could exert lingering effects on dopaminergic pathways in the brain and whether colitis increased vulnerability to a subsequent exposure to the dopaminergic neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.