Tag results:
lymphoid cells
Human Immunology News
p16INK4a Regulates Cellular Senescence in PD-1-Expressing Human T Cells
[Frontiers in Immunology] Using various clinically and physiologically relevant systems, researchers showed that a prominent feature of PD-1-expressing exhausted T cells was the development of cellular senescence features both in vivo and ex vivo.
Human Immunology News
Chronological Genome and Single-Cell Transcriptome Integration Characterizes the Evolutionary Process of Adult T Cell Leukemia-Lymphoma
[Nature Communications] Scientists developed and utilized a capture-based sequencing panel, which covered host hotspot genes and the full-length genome of human T-cell leukemia virus type-1, to investigate the clonal architecture of adult T-cell leukemia-lymphoma.
Human Immunology News
Targeting the DNA Damage Response in Immuno-Oncology: Developments and Opportunities
[Nature Reviews Cancer] Scientists discuss the interplay between the DNA damage response and anticancer immunity and highlight how this dynamic interaction contributes to shaping tumour immunogenicity.
Human Immunology News
Tumor-Conditional IL-15 Pro-cytokine Reactivates Anti-Tumor Immunity with Limited Toxicity
[Cell Research] Investigators developed a next-generation IL-15 that is activated inside the tumor microenvironment.
Immunology of Infectious Disease News
An AAV-Based, Room-Temperature Stable, Single Dose COVID-19 Vaccine Provides Durable Immunogenicity and Protection in Non-Human Primates
[Cell Host & Microbe] AAVCOVID-1, an adeno-associated viral (AAV), spike gene-based vaccine candidate demonstrated potent immunogenicity in mouse and nonhuman primates following a single injection and conferred complete protection from SARS-CoV-2 challenge in macaques.
Immunology of Infectious Disease News
EBNA2 Driven Enhancer Switching at the CIITA-DEXI Locus Suppresses HLA Class II Gene Expression during EBV Infection of B-Lymphocytes
[PLOS Pathogens] Investigators identified a major EBNA2 binding site downstream of the CIITA gene and upstream of DEXI, a dexamethasone inducible gene that is oriented head-to-head with CIITA gene transcripts.