lymphoid cells

[Molecular Therapy] Scientists isolated a broad range of promising TCRs targeting multiple antigens for treatment of B-cell malignancies. 28 target genes for B-cell malignancies were selected based on gene expression profiles.

[Molecular Therapy] Investigators outline how epigenetic modifications in CAR T cells can overcome barriers limiting CAR T cell effectiveness, particularly in immunosuppressive tumor microenvironments.

[Nature Communications] The authors utilized an engineered microbial organism with a six-letter semi-synthetic DNA code to generate a library of site-specific, click chemistry compatible amino acid substitutions in the human cytokine IL-2.

[Oncogene] Researchers explored the inhibitory role of ITLN1 in the tumor-permissive microenvironment that existed during the first occurrence and subsequent development of colorectal carcinoma.

[GeekWire] Sonoma Biotherapeutics has raised $265 million in new funding which will be used to advance its programs aiming to treat autoimmune and inflammatory conditions such as rheumatoid arthritis, type 1 diabetes, and IBD.

[Nature Communications] Lesional skin of non-responders contains higher numbers of dermal dendritic cells expressing the maturation marker CD83 and producing IL-23, and increased numbers of IL-17+ T cells.