lymphoid cells

[Digestive and Liver Disease] Scientists summarize the current knowledge of how different crosstalk between liver sinusoidal endothelial cells and other liver cells, including hepatocytes, hepatic stellate cells, macrophoges, immune cells in liver and extra cellular matrix contribute to the physiological function and the progrssion from liver fibrosis to cirrhosis, or even to hepatocellular carcinoma.

[Nature Communications] Investigators showed that MR1-restricted mucosal-associated invariant T (MAIT) cell-deficient mice have enhanced NK cell-dependent control of metastatic B16F10 tumor growth relative to control mice.

[Moderna, Inc.] Moderna, Inc. announced the first participant has been dosed in the Phase I study of mRNA-6231, the company’s mRNA-encoded IL-2 modified for the expansion of regulatory T cells.

[Scientific Reports] The authors developed an in vitro cell model in which human acute lymphoblastic leukemia cells were grown in co-culture with human derived bone marrow stromal cells or osteoblasts to interrogate a clinically relevant population of treatment refractory cells.

[Cancer Cell] Using multiple preclinical models of neoantigen-expressing pancreatic adenocarcinoma (PDAC), scientists demonstrated that intratumoral neoantigen-specific CD8+ T cells adopted multiple states of dysfunction, resembling those in tumor-infiltrating lymphocytes of PDAC patients.

[Science Translational Medicine] The authors found that anti–cytotoxic T lymphocyte–associated protein 4 (CTLA-4)×SIRPα preferentially depleted ICOShigh immunosuppressive Treg cells in the tumor microenvironment and enhanced immunity against solid tumors, including MC38 and CT26 murine colon cancers.