lymphoid cells

[Immunity] Scientists examined the immunological features and metabolic microenvironment of untreated individuals with inflammatory bowel disease by multiomics analyses.

[Immunity] Researchers focused on IL4I1+CD274(PD-L1)+IDO1+ macrophages, which accumulated in the tumor periphery in a T cell-dependent manner via interferon-γ (IFN-γ) and CD40/CD40L-induced maturation from IFN-primed monocytes.

[Nature Reviews Rheumatology] The authors describe the importance of lymphocyte-stromal cell interactions in chronic inflammation, with a focus on human disease, using three selected autoimmune and inflammatory diseases.

[Nature Communications] Scientists reported SARS-CoV-2 specific T cell responses in infected adults and children and find that the acute and memory CD4+ T cell responses to structural SARS-CoV-2 proteins increase with age, whereas CD8+ T cell responses increase with time post-infection.

[Journal of Clinical Oncology] In this single-center, Phase I trial, researchers administered anti-CD7 chimeric antigen receptor (CAR) T cells, manufactured from either previous stem-cell transplantation donors or new donors, to patients with relapsed or refractory T-cell acute lymphoblastic leukemia, in single infusions at doses of 5 × 105 or 1 × 106 cells per kilogram of body weight.

[Cancer Immunology Research] Investigators found that although NK cells did not express endogenous TYRO3 on the cell surface, activated NK cells rapidly acquired TYRO3 from tumor cells via trogocytosis in vitro and in vivo.