lymphoid cells

[Nature Immunology] The authors confirmed pervasive phenotypic, functional and transcriptional differences between memory and exhausted antigen-specific CD8+ T cells in human hepatitis C virus infection before and after treatment.

[Cell Reports] Type 1 diabetes (T1D) patients had a lower serum MOTS-c level than did healthy controls. Furthermore, MOTS-c reduced T cell activation by alleviating T cells from the glycolytic stress in T1D patients, suggesting therapeutic potential.

[eLife] Using primary human CD4+ T cells, researchers showed that when T cells form immunological synapse with stimulating antibody-coated surfaces, the lamellipodia are stiffer than the cell body.

[Cancer Gene Therapy] Scientists reported that extracellular vesicles derived from human natural killer-92 cells stimulated with IL-15 + IL-21 showed enhanced cytotoxic capacity against tumor cells.

[Scientific Reports] The authors used recently described RNA ligands for toll-like receptor (TLR)7 and TLR8 together with Vγ9Vδ2 T-cell specific pyrophosphate antigens to analyze the rapid cytokine induction in Vδ2 T cells as well as the accessory cell requirements.

[Leukemia] In this Phase I/II clinical trial, the authors investigated the safety and efficacy of high doses of mb-IL21 ex vivo expanded donor-derived NK cells to decrease relapse in 25 patients with myeloid malignancies receiving haploidentical stem-cell transplantation.