lymphoid cells

[Cell Reports] Mass spectrometry analysis on the supernatant of human melanoma cells revealed 12 peptides capable of priming healthy-donor CD8+ T cells that recognized and killed human melanoma cells in vitro and when xenotransplanted in vivo.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers suggested that missense p53 mutations may have contributed to worse PDAC prognosis by promoting a more vigorous fibrotic tumor microenvironment and impeded the ability of the immune system to eliminate the cancer cells.

[Laboratory Investigation] The authors investigated the role of hypoxia/serum deprivation-induced M1-type macrophage-derived exosomes on bone marrow MSC viability, migration, and apoptosis.

[Abcuro, Inc.] Abcuro, Inc. and ImaginAb shared initial results of a study demonstrating the use of ImmunoPET technology to image T cell infiltration of skeletal muscle in patients with inclusion body myositis, an autoimmune disease in which cytotoxic CD8+ T cells chronically attack muscle cells, leading to progressive weakness and severe disability.

[Leukemia] The authors built mouse models expressing activated Il7r (aIL7R). B-cell intrinsic aIL7R mice developed spontaneous B-cell acute lymphoblastic leukemia, demonstrating sufficiency of Il7r activating mutations in leukemogenesis.

[Haematologica] Tafasitamab combined with the immunomodulatory drug lenalidomide was clinically active with a good tolerability profile in the open-label, single-arm, phase II L-MIND study of autologous stem-cell transplant-ineligible patients with relapsed/refractory diffuse large B-cell lymphoma.