lymphoid cells

[Nature Immunology] Using a novel HLA-DRB1*15:01/S751 tetramer to track spike-specific CD4+ T cells, scientists showed that primary infection or vaccination induced robust S751-specific CXCR5− and cTFH cell memory responses.

[Immunogenetics] The authors investigated the effect of Myd88 silencing on dendritic cell function and immune response. CD34+ cells were isolated from the bone marrow of rhesus monkeys by the immunomagnetic bead method and then infected with an adenovirus expressing Myd88-specific short hairpin RNA.

[Cell Reports] Investigators reported that serine 182 phosphorylation was a major post-translational modification was not involved in thymic T cell development and effector T cell differentiation.

[Cancer Immunology Research] Using an aggressive melanoma tumor model, the authors targeted PSGL-1 in tumor-bearing mice and found increased effector CD4+ and CD8+ T cell responses and decreased regulatory T cells in tumors.

[Nature Communications] The authors reported SARS-CoV-2 vaccine-induced immune responses and breakthrough infections in patients with inflammatory bowel disease, who were treated either with an anti-tumor necrosis factor antibody, infliximab, or with vedolizumab targeting a gut-specific anti-integrin that did not impair systemic immunity.

[Nature Aging] The authors showed that branching of asparagine-linked glycans increased with age in females more than in males, in naive T cells more than in memory T cells, and in CD4+ more than in CD8+ T cells.