lymphoid cells

[Nature Immunology] Researchers showed that the transcription factor Tcf1 was required in resting central memory CD8+ T cells to generate secondary effector CD8+ T cells and to clear pathogens during recall responses.

[Cell Reports] Investigators found that diminished expression of a model tissue-restricted antigen gene in aged thymic stromal cells correlated with impaired clonal deletion of cognate T cells recognizing an autoantigen involved in atherosclerosis.

[Science Immunology] Researchers investigated how changes to naive CD8+ T cell gene expression depended on the basic leucine zipper ATF-like transcription factor Batf, which was essential for the early phases of the process.

[International Immunopharmacology] Scientists found that C-C motif chemokine ligand 2 (CCL2) recruits monocytes to and decrease CD8+ T cell infiltration in pancreatic tumors.

[International Immunopharmacology] Scientists found that C-C motif chemokine ligand 2 (CCL2) recruits monocytes to and decrease CD8+ T cell infiltration in pancreatic tumors.

[Scientific Reports] In patients achieving a complete response (CR) transcriptomic profiles of bone marrow prior to lymphodepletion showed genes mainly involved in T cell activation.