lymphoid cells

[Bone Research] Using genetically modified mice and high-throughput analyses, scientists demonstrated that prolonged hypoxia-inducible factor (HIF)-1α signaling in B cells led to enhanced eceptor activator of nuclear factor kappa-Β production and osteoclast formation.

[Advanced Materials] Researchers investigated the immunological effect of chiral nanomaterials as therapeutic and preventive options against tumors.

[Mucosal Immunology] Scientists reported specifically elevated expression of IL-36α, and not IL-36β or IL-36γ in the serum of newly diagnosed, treatment naïve, pediatric inflammatory bowel diseases patients and identify T cells as primary cellular mediators of IL-36 responses in the inflamed gut.

[Endocrine Journal] Human umbilical cord mesenchymal stem cells treatment significantly alleviated inflammation, reduced serum thyroid antibody levels, and decreased the ratios of IL-17α+/CD25+FOXP3+ cells and serum IFN-γ/IL-4 in experimental autoimmune thyroiditis rats.

[Celularity Inc.] Celularity Inc. announced the US FDA has granted Orphan Drug Designation for its investigational natural killer cell therapy, CYNK-101, for treatment of gastric/gastroesophageal junction cancer.

[Nature Communications] Researchers showed that a subset of Interleukin-10-releasing HMOX1+ myeloid cells, spatially localizing to mesenchymal-like tumor regions, drove T cell exhaustion and thus contributed to the immunosuppressive tumor microenvironment.