lymphoid cells

[Journal of Clinical Investigation] Investigators observed that anti–PD-1 therapy depends on IL-2 signaling, which raised the possibility that a lack of IL-2 limited anti–PD-1–induced effector T cell expansion.

[Science Advances] eEF-2K KO CD8+ T cells were more metabolically active and showed hyperactivation of the Akt-mTOR-S6K pathway.

[Science Advances] The authors demonstrated that aspirin increased concentrations of the immune-regulatory aspirin-triggered (AT) specialized proresolving mediators, including AT-lipoxin A4 and AT-resolvin D1, in colonic tissues during inflammation-associated colorectal cancer.

[Chemico-Biological interactions] Scientists discuss the medical value of nutraceuticals briefly and their ability to mitigate various inflammatory lung diseases through targeting inhibition of NF-κB.

[Cell Death & Disease] Niclosamide inhibited proliferation of pancreatic cancer cells, induced apoptosis via the mitochondrial-mediated pathway, and suppressed cell migration and invasion by antagonizing epithelial-to-mesenchymal transition.

[Nature] CAR T cells remained detectable more than ten years after infusion, with sustained remission in both patients.