The Impact of Donor Type on the Outcome of Pediatric Patients with Very High Risk Acute Lymphoblastic Leukemia: A Study of the ALL SCT 2003 BFM-SG and 2007-BFM-International SG

Two consecutive international prospective studies, ALL- stem cell transplantation (SCT)-(I)BFM 2003 and 2007 were conducted in 1150 pediatric patients. 569 presented with very high risk disease leading to any kind of hematopoietic SCT.
[Bone Marrow Transplantation]
Dalle, J.-H., Balduzzi, A., Bader, P., Pieczonka, A., Yaniv, I., Lankester, A., Bierings, M., Yesilipek, A., Sedlacek, P., Ifversen, M., Svec, P., Toporski, J., Gungor, T., Wachowiak, J., Glogova, E., Poetschger, U., & Peters, C. (2020). The impact of donor type on the outcome of pediatric patients with very high risk acute lymphoblastic leukemia. A study of the ALL SCT 2003 BFM-SG and 2007-BFM-International SG. Bone Marrow Transplantation, 1–10. https://doi.org/10.1038/s41409-020-01014-x Cite
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Impact of Donor Source on Allogeneic Hematopoietic Stem Cell Transplantation for Mature T- and NK-Cell Neoplasms in the Kyoto Stem Cell Transplantation Group

39 patients received bone marrow or peripheral blood stem cell transplantation from related donors, 37 received BMT/PBSCT from unrelated donors, and 35 received cord blood transplantation
[Biology of Blood and Marrow Transplantation]
Watanabe, M., Kanda, J., Arai, Y., Hishizawa, M., Nishikori, M., Ishikawa, T., Imada, K., Ueda, Y., Akasaka, T., Yonezawa, A., Nohgawa, M., Kitano, T., Itoh, M., Takeoka, T., Moriguchi, T., Yago, K., Arima, N., Anzai, N., Watanabe, M., … Takaori-Kondo, A. (2020). Impact of donor source on allogeneic hematopoietic stem cell transplantation for mature T- and NK-cell neoplasms in the Kyoto Stem Cell Transplantation Group. Biology of Blood and Marrow Transplantation, 0(0). https://doi.org/10.1016/j.bbmt.2020.07.032 Cite
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Immune Phenotyping of Diverse Syngeneic Murine Brain Tumors Identifies Immunologically Distinct Types

Researchers generated distinct imageable syngeneic mouse glioblastoma-tumor models and utilized RNA-sequencing, CyTOF and correlative immunohistochemistry to assess immune-profiles in these models.
[Nature Communications]
Khalsa, J. K., Cheng, N., Keegan, J., Chaudry, A., Driver, J., Bi, W. L., Lederer, J., & Shah, K. (2020). Immune phenotyping of diverse syngeneic murine brain tumors identifies immunologically distinct types. Nature Communications, 11(1), 3912. https://doi.org/10.1038/s41467-020-17704-5 Cite
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Dissection of α4β7 Integrin Regulation by Rap1 Using Novel Conformation-Specific Monoclonal Anti-β7 Antibodies

The small GTPase Rap1 deficiency, as well as chemokine stimulation and the introduction of the active form of Rap1, Rap1V12, enhanced the binding of NZ-1 to the PA-tagged mutant integrin, and increased the binding affinity to mucosal addressing cell adhesion molecule-1.
[Scientific Reports]
Sato, T., Ishihara, S., Marui, R., Takagi, J., & Katagiri, K. (2020). Dissection of α 4 β 7 integrin regulation by Rap1 using novel conformation-specific monoclonal anti-β 7 antibodies. Scientific Reports, 10(1), 13221. https://doi.org/10.1038/s41598-020-70111-0 Cite
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Immunometabolism and HIV-1 Pathogenesis: Food for Thought

The authors summarize current knowledge of the links between HIV-1 infection and immunometabolism, and they discuss the potential opportunities and challenges for therapeutic interventions.
[Nature Reviews Immunology]
Sáez-Cirión, A., & Sereti, I. (2020). Immunometabolism and HIV-1 pathogenesis: food for thought. Nature Reviews Immunology, 1–15. https://doi.org/10.1038/s41577-020-0381-7 Cite
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Single-Cell Analysis of Two Severe COVID-19 Patients Reveals a Monocyte-Associated and Tocilizumab-Responding Cytokine Storm

By employing single-cell analysis of the immune cell composition of two severe-stage COVID-19 patients prior to and following tocilizumab-induced remission, investigators identified a monocyte subpopulation that contributes to the inflammatory cytokine storms.
[Nature Communications]
Guo, C., Li, B., Ma, H., Wang, X., Cai, P., Yu, Q., Zhu, L., Jin, L., Jiang, C., Fang, J., Liu, Q., Zong, D., Zhang, W., Lu, Y., Li, K., Gao, X., Fu, B., Liu, L., Ma, X., … Qu, K. (2020). Single-cell analysis of two severe COVID-19 patients reveals a monocyte-associated and tocilizumab-responding cytokine storm. Nature Communications, 11(1), 3924. https://doi.org/10.1038/s41467-020-17834-w Cite
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Elevation in the Counts of IL-35-Producing B Cells Infiltrating into Lung Tissue in Mycobacterial Infection Is Associated with the Downregulation of Th1/Th17 and Upregulation of Foxp3+Treg

Purified B cells from such patients generated more IL-35 after stimulation by antigens of Mycobacterium tuberculosis and secreted more IL-10.
[Scientific Reports]
Chen, C., Xu, H., Peng, Y., Luo, H., Huang, G.-X., Wu, X.-J., Dai, Y.-C., Luo, H.-L., Zhang, J.-A., Zheng, B.-Y., Zhang, X.-N., Chen, Z. W., & Xu, J.-F. (2020). Elevation in the counts of IL-35-producing B cells infiltrating into lung tissue in mycobacterial infection is associated with the downregulation of Th1/Th17 and upregulation of Foxp3 + Treg. Scientific Reports, 10(1), 13212. https://doi.org/10.1038/s41598-020-69984-y Cite
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Pharmacological Activation of the Circadian Component REV-ERB Inhibits HIV-1 Replication

Researchers investigated whether REV-ERB activity regulates HIV-1 replication and found REV-ERB agonists inhibited HIV-1 promoter activity in cell lines, primary human CD4 T cells and macrophages, whilst antagonism or genetic disruption of REV-ERB increased promoter activity.
[Scientific Reports]
Borrmann, H., Davies, R., Dickinson, M., Pedroza-Pacheco, I., Schilling, M., Vaughan-Jackson, A., Magri, A., James, W., Balfe, P., Borrow, P., McKeating, J. A., & Zhuang, X. (2020). Pharmacological activation of the circadian component REV-ERB inhibits HIV-1 replication. Scientific Reports, 10(1), 13271. https://doi.org/10.1038/s41598-020-70170-3 Cite
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Hematopoietic Stem Cell Transplantation and Chimeric Antigen Receptor T Cell for Relapsed or Refractory Diffuse Large B-Cell Lymphoma

Scientists treated 14 relapsed or refractory diffuse large B-cell lymphoma patients by combining autologous hematopoietic stem cell transplantation and anti-CD19 chimeric antigen receptor T-cell therapy.
[Immunotherapy]
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Development of an Artificial Antibody Specific for HLA/Peptide Complex Derived from Cancer Stem-Like Cell/Cancer-Initiating Cell Antigen DNAJB8

Investigators developed a therapeutic single-chain variable-fragment antibody that recognises the cancer stem-like cell/cancer-initiating cell antigen, DNAJB8.
[British Journal of Cancer]
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Cytovia Therapeutics Acquires Worldwide Rights to CytoImmune Therapeutics’ First-In-Class EGFR Dual-Targeting CAR for NK Cell Treatment of Glioblastoma & Other Solid Tumors

Cytovia Therapeutics, Inc announced that it has acquired worldwide rights from CytoImmune Therapeutics for its novel EGFR dual-targeting CAR to be used for NK cell therapy.
[Cytovia Therapeutics, Inc. (GlobeNewswire, Inc.)]
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