Azacitidine-Induced Reconstitution of the Bone Marrow T Cell Repertoire Is Associated with Superior Survival in AML Patients

Since hypomethylating agents possessed immunomodulatory functions that constituted part of their anti-tumor effect, the authors set out to analyze the bone marrow immune environment by next-generation sequencing of T cell receptor beta repertoires in 51 AML patients treated within the RAS-AZIC trial.