macrophages

[Clinical Cancer Research] Researchers characterized changes in the soft tissue sarcoma tumor immune microenvironment induced by standard neoadjuvant therapy with the goal of informing neoadjuvant immunotherapy trial design.

[Cell Death & Disease] The authors investigated the impact of apoptotic colorectal cancer cells on neutrophils and its consequence on other immune cells of the tumor microenvironment.

[Cell Metabolism] Researchers combined cell-type-resolved genomics and computational approaches to map crosstalk between hepatocytes and liver macrophages during fasting.

[Science Translational Medicine] Investigators found that distant metastases were more immune inert with increased M2 macrophages compared to their matched primary tumors.

[Science Advances] The authors demonstrated that aspirin increased concentrations of the immune-regulatory aspirin-triggered (AT) specialized proresolving mediators, including AT-lipoxin A4 and AT-resolvin D1, in colonic tissues during inflammation-associated colorectal cancer.

[Cancer Gene Therapy] Researchers demonstrated that bone marrow MSC-derived extracellular vesicles carrying NEAT1 could promote the progression of melanoma by inducing M2 polarization of macrophages, and thus may be considered as a potential target for melanoma therapeutics.