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macrophages

TIM-3 Shuttled by MV3 Cells-Secreted Exosomes Inhibits CD4+ T Cell Immune Function and Induces Macrophage M2 Polarization to Promote the Growth and Metastasis of...

[Translational Oncology] Silencing of TIM-3 shuttled by MV3 cells-derived exosomes improved CD4+ T cell immune function and inhibited macrophage M2 polarization to attenuate the growth and metastasis of melanoma cells.

Characterizing Cellular Heterogeneity in Fibrotic Hypersensitivity Pneumonitis by Single-Cell Transcriptional Analysis

[Cell Death Discovery] Utilizing an integrated strategy based on scRNA-seq, scTCR-seq, and bulk RNA-seq analysis of fibrotic hypersensitivity pneumonitis profiles, the authors identified ten major cell types and 19 unique subtypes.

Integrative Bioinformatics and Experimental Analysis Revealed TEAD as Novel Prognostic Target for Hepatocellular Carcinoma and Its Roles in Ferroptosis Regulation

[Aging] Investigators indicated that TEAD2/4 were significantly upregulated in HCC compared with normal tissues. Downregulation of TEAD2 promoted the death of HCC cells through inducing ferroptosis by iron accumulation and subsequent oxidative damage.

Integrated Histopathological, Lipidomic, and Metabolomic Profiles Reveal Mink Is a Useful Animal Model to Mimic the Pathogenicity of Severe COVID-19 Patients

[Signal Transduction and Targeted Therapy] The authors demonstrated that minks were largely permissive to SARS-CoV-2, characterized by severe and diffuse alveolar damage, and lasted at least 14 days post inoculation.

Mechanism of miR-378a-3p Enriched in M2 Macrophage-Derived Extracellular Vesicles in Cardiomyocyte Pyroptosis after MI

[Hypertension Research] An in vitro cell model was established, followed by a comprehensive evaluation of cell viability and pyroptosis. The binding relationships of miR-378a-3p and ELAVL1, HuR, and NLR family pyrin domain containing 3 were analyzed.

Extracellular Vesicles from Adipose-Derived Stem Cells Promote Microglia M2 Polarization and Neurological Recovery in a Mouse Model of Transient Middle Cerebral Artery Occlusion

[Current Stem Cell Research & Therapy] The authors explored the contribution of miRNAs in adipose-derived stem cell-extracellular vesicles to the treatment of cerebral ischemia.

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