macrophages

[Proceedings of the National Academy of Sciences of the United States of America] 12,13-dihydroxyoctadecenoic acid was found to facilitate the maturation and activation of stimulated neutrophils, while impeding monocyte and macrophage functionality and cytokine generation.

[Infection and Immunity] Investigators compare the fundamental differences between alveolar macrophages and circulating monocyte-derived macrophages in the context of tuberculosis and summarize the recent advances in elucidating the epigenomes of these cells.

[Nature Communications] Pannexin-1 on endothelial cells acted as a conduit for ATP release that stimulated macrophage activation via P2X7 receptors and mitochondrial DNA release to increase IL-1β and HMGB1 secretion.

[Proceedings of the National Academy of Sciences of the United States of America] The authors identified the importance of the hypoxia-inducible lipid droplet–associated protein and the intracellular adipose triglyceride lipase in the regulation of lipid accumulation and breakdown in inflammatory macrophages.

[Scientific Reports] Scientists investigated the anti-inflammatory effects of MSCs on lipopolysaccharide-stimulated macrophages and the subsequent downregulation of their inflammatory mediators.

[Journal of Hepatology] Researchers investigated the role of X-box binding protein-1 (XBP1) in the progression of non-alcoholic steatohepatitis.