Endothelial Pannexin-1 Channels Modulate Macrophage and Smooth Muscle Cell Activation in Abdominal Aortic Aneurysm Formation

Pannexin-1 on endothelial cells acted as a conduit for ATP release that stimulated macrophage activation via P2X7 receptors and mitochondrial DNA release to increase IL-1β and HMGB1 secretion.