mammary cells

[Cancer Cell International] Investigators explored bone metastasis-related long non-coding RNAs (lncRNAs) in breast cancer and found that four LncRNA-mRNA pairs, including LOC641518-LEF1, may have played a central role in breast cancer bone metastasis.

[Molecular Cancer therapeutics] Depletion or inhibition of WNK1 reduced migration of several breast cancer cell lines in wound healing assays and decreased invasion in collagen matrices.

[Scientific Reports] The authors investigated potential correlations between electrical characteristics and biomarkers of breast cancer cells (BCCs). Changes in σ and ε of different components in suspensions of normal cells and BCCs were analyzed in the range of 200 kHz–5 MHz.

[British Journal of Cancer] Scientists identified the consistent transcriptome of primary breast cancer stem cells (BCSCs) shared across breast cancer subtypes, and examined the clinical relevance of ITGA7, one of the genes differentially expressed in BCSCs.

[Developmental Cell] The authors review how cell fate decisions are regulated by components of the microenvironment during mammary gland development and how pathological changes in the microenvironment can alter cell fates, leading to malignancy.

[Oncogene] Mesenchymal stem cells and cancer-associated fibroblasts expressed high PEAK1 protein levels and potentiated tumorigenesis, lapatinib resistance and metastasis of HER2-positive breast cancer cells in a PEAK1-dependent manner.