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mammary cells

Cannabics Pharmaceuticals Launches a Breast Cancer Treatment Research Program

[Cannabics Pharmaceuticals, Inc. (PR Newswire, Inc.)] Cannabics Pharmaceuticals, Inc. announced the launching of a new research program for the development of a breast cancer antitumor targeting medicine following the successful completion of a series of preclinical experiments.

ETV4 Promotes Breast Cancer Cell Stemness by Activating Glycolysis and CXCR4-Mediated Sonic Hedgehog Signaling

[Cell Death Discovery] Regulation of cancer cell metabolism rewiring and stemness is not completely understood. Scientists reported that ETV4 is a key transcription factor in regulating glycolytic gene expression.

Syndecan-1 Depletion Has a Differential Impact on Hyaluronic Acid Metabolism and Tumor Cell Behavior in Luminal and Triple-Negative Breast Cancer Cells

[International Journal of Molecular Sciences] Investigators studied the effect of syndecan-1 siRNA depletion and hyaluronic acid treatment on hallmark processes of cancer in breast cancer cell lines of different levels of aggressiveness.

Low-Dose CDK4/6 Inhibitors Induce Presentation of Pathway Specific MHC Ligands as Potential Targets for Cancer Immunotherapy

[Oncoimmunology] Researchers investigated the effects of CDK4/6i, abemaciclib and palbociclib, on the immunopeptidome at nontoxic levels in breast cancer cell lines using biochemical identification of HLA ligands followed by network analyses.

SEC61G Promotes Breast Cancer Development and Metastasis via Modulating Glycolysis and Is Transcriptionally Regulated by E2F1

[Cell Death & Disease] Scientists investigated the expression and function of SEC61G in breast cancer, and demonstrated that knockdown of SEC61G suppressed breast cancer cell proliferation, migration, invasion, and promoted breast cancer cell apoptosis in vitro.

Small Molecule Inhibitors of the Mitochondrial ClpXP Protease Possess Cytostatic Potential and Re-Sensitize Chemo-Resistant Cancers

[Scientific Reports] Scientists screened previously established S. aureus ClpXP inhibitors against the related human protease complex and identified potent small molecules against human ClpXP. The hit compounds showed anti-cancer activity in a panoply of leukemia, liver and breast cancer cell lines.

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