mammary stem cells

[Trends in Cell Biology] The author highlights misconceptions, suggest definitions of stem and progenitor cells, and propose a way forward in the search for an understanding of mammary stem cells.

[Stem Cell Reports] Researchers investigated the roles of p53, p16INK4a, and p19ARF in the regulation of self-renewal and proliferation of mammary epithelial cells.

[Stem Cell Reports] Researchers utilized an inducible, conditional knockout of Tfap2c to elucidate the role of AP-2γ in maintenance and differentiation of mammary stem cells.

[Neoplasia] Two models have been proposed to explain the cell of origin of breast cancer and involve either the reprogramming of differentiated mammary cells or the dysregulation of mammary stem cells or progenitors. Both hypotheses are not exclusive and imply the accumulation of independent mutational events.

[Seminars in Cell & Developmental Biology] Investigators provide an overview of the latest research in the single-cell genomics of mammary gland development, which may help to understand the lineage commitment of mammary stem cells into luminal or basal epithelial cells that constitute the mammary gland.

[Nature Communications] Scientists revealed that TET2 played a pivotal role in mammary gland development and luminal lineage commitment.