Depletion of Trp53 and Cdkn2a Does Not Promote Self-Renewal in the Mammary Gland but Amplifies Proliferation Induced by TNF-α

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Researchers investigated the roles of p53, p16INK4a, and p19ARF in the regulation of self-renewal and proliferation of mammary epithelial cells.
[Stem Cell Reports]
Pai Bellare, G., Saha, B., & Patro, B. S. (2021). Targeting autophagy reverses de novo resistance in homologous recombination repair proficient breast cancers to PARP inhibition. British Journal of Cancer, 1–15. https://doi.org/10.1038/s41416-020-01238-0 Cite
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