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Pulmonary Cell NewsTwo models have been proposed to explain the cell of origin of breast cancer and involve either the reprogramming of differentiated mammary cells or the dysregulation of mammary stem cells or progenitors. Both hypotheses are not exclusive and imply the accumulation of independent mutational events.
[Neoplasia]
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Taurin, S., & Alkhalifa, H. (2020). Breast cancers, mammary stem cells, and cancer stem cells, characteristics, and hypotheses. Neoplasia, 22(12), 663–678. https://doi.org/10.1016/j.neo.2020.09.009 Cite
