Iron Deficiency as Promoter of Heavy Metals-Induced Acute Myeloid Leukemia

Scientists discuss in detail the mechanisms involved in accumulation of cadmium in particular cell lines of the bone marrow and the consequent occurrence of acute myeloid leukemia.
[Leukemia Research]
[zotpress userid=” items=’BBBBBBBB’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

CD62L Expression Level Determines the Cell Fate of Myeloid Progenitors

Scientists identified CD62L as a marker to reveal the heterogeneity within progenitors. They confirmed that CD62L-negative common myeloid progenitors (CMPs) represent “bona fide” CMPs, and CD62L-high CMPs are mostly restricted to granulocyte-monocyte progenitors potentials in mice and humans.
[Stem Cell Reports]
[zotpress userid=” items=’BBBBBBBB’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Toward Platelet Transcriptomics in Cancer Diagnosis, Prognosis and Therapy

The authors present a few actionable steps for basic, translational and clinical research communities in advancing the utility of the platelet transcriptome as a highly sensitive biomarker in cancer and collectively enable efforts toward clinical translation and patient benefit.
[British Journal of Cancer]
[zotpress userid=” items=’BBBBBBBB’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Therapeutic Use of Red Blood Cells and Platelets Derived from Human Cord Blood Stem Cells

In this review, the gap between the many basic studies and limited clinical trials on stem cell-derived RBCs and platelets is summarized.
[Stem Cells Translational Medicine]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Myelodysplastic/Myeloproliferative Neoplasms-Unclassifiable with Isolated Isochromosome 17q Represents a Distinct Clinico-Biologic Subset: A Multi-Institutional Collaborative Study from the Bone Marrow Pathology Group

Classification of myeloid neoplasms with isolated isochromosome i(17q) is controversial. Most cases fall within the WHO unclassifiable myelodysplastic/myeloproliferative neoplasms (MDS/MPN-U) category. Researchers undertook a multi-institutional retrospective study of 92 adult MDS/MPN-U cases from eight institutions.
[Modern Pathology]
[zotpress userid=” items=’BBBBBBBB’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

CALR Frameshift Mutations in MPN Patient-Derived iPSCs Accelerate Maturation of Megakaryocytes

Scientists generated patient-derived CALRins5- or CALRdel52-positive iPSCs to establish a myeloproliferative neoplasms disease model for molecular and mechanistic studies.
[Stem Cell Reports]
[zotpress userid=’7992332′ items=’DDDDDDDD’ style=’apa’ cite=’yes’]
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

Share

Regulatory Association of Long Noncoding RNAs and Chromatin Accessibility Facilitates Erythroid Differentiation

The authors employed HSCs, multipotent progenitor cells, common myeloid progenitor cells, megakaryocyte-erythroid progenitor cells, and erythroblasts from human cord blood as an erythroid differentiation model to explore the coordinated regulatory functions of lncRNAs and chromatin accessibility by integrating RNA-Seq and ATAC-Seq data.
[Blood Advances]
[zotpress userid=’7992332′ items=’BBBBBBBB’ style=’apa’ cite=’yes’]
AbstractFull Article
Bookmark

No account yet? Register

Share

Human Induced Pluripotent Stem Cell-Derived Platelets Loaded with Lapatinib Effectively Target HER2+ Breast Cancer Metastasis to the Brain

Investigators described methods for ex vivo generation of megakaryocytes and functional platelets from human induced pluripotent stem cells in a scalable fashion.
[Scientific Reports]
[zotpress userid=’7992332′ items=’CCCCCCCC’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Clinical and Biological Aspects of Myeloid Leukemia in Down Syndrome

Despite advances in understanding the clinical and biological aspects of myeloid leukemia in children with Down syndrome (DS), little is known about the mechanisms of relapse. Upon relapse, patients face a poor outcome, and there is no consensus on treatment. Future studies need to be focused on this challenging aspect of leukemia in children with DS.
[Leukemia]
[zotpress userid=’7992332′ items=’BBBBBBBB’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Insufficiency of Non-Canonical PRC1 Synergizes with JAK2V617F in the Development of Myelofibrosis

The authors investigated the impact of PRC1.1 insufficiency on myelofibrosis. Transcriptome and chromatin immunoprecipitation sequence analysis showed the de-repression of PRC1.1 target genes in Pcgf1-deficient JAK2V617F hematopoietic progenitors and revealed Hoxa cluster genes as direct targets.
[Leukemia]
[zotpress userid=’7992332′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Immune Cells Surveil Aberrantly Sialylated O-Glycans on Megakaryocytes to Regulate Platelet Count

Interferon-producing Siglec H-positive bone marrow immune cells engaged with O-glycan sialic acid moieties to regulate type I interferon secretion and platelet release, as evidenced by partially normalized platelet count following and inhibition of interferon and Siglec H receptors.
[Blood]
[zotpress userid=’7992332′ items=’SFVRCNC7′ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share
Share