Deletion of Grin1 in Mouse Megakaryocytes Reveals NMDA Receptor Role in Platelet Function and Proplatelet Formation

Researchers found that Pf4-Grin1-/- mice had defects in megakaryopoiesis, thrombopoiesis and platelet function, which manifested as reduced platelet counts, lower rates of platelet production in the immune model of thrombocytopenia, and a prolonged tail bleeding time.