megakaryocytes

[Scientific Reports] Investigators described methods for ex vivo generation of megakaryocytes and functional platelets from human induced pluripotent stem cells in a scalable fashion.

[Blood Advances] The authors employed HSCs, multipotent progenitor cells, common myeloid progenitor cells, megakaryocyte-erythroid progenitor cells, and erythroblasts from human cord blood as an erythroid differentiation model to explore the coordinated regulatory functions of lncRNAs and chromatin accessibility by integrating RNA-Seq and ATAC-Seq data.

[Leukemia] Despite advances in understanding the clinical and biological aspects of myeloid leukemia in children with Down syndrome (DS), little is known about the mechanisms of relapse. Upon relapse, patients face a poor outcome, and there is no consensus on treatment. Future studies need to be focused on this challenging aspect of leukemia in children with DS.

[Leukemia] The authors investigated the impact of PRC1.1 insufficiency on myelofibrosis. Transcriptome and chromatin immunoprecipitation sequence analysis showed the de-repression of PRC1.1 target genes in Pcgf1-deficient JAK2V617F hematopoietic progenitors and revealed Hoxa cluster genes as direct targets.

[Blood] Interferon-producing Siglec H-positive bone marrow immune cells engaged with O-glycan sialic acid moieties to regulate type I interferon secretion and platelet release, as evidenced by partially normalized platelet count following and inhibition of interferon and Siglec H receptors.

[Platelets] Investigators found that the plant hormone abscisic acid could increase the generation of megakaryocytes and platelets from human iPSCs.