Immune Cells Surveil Aberrantly Sialylated O-Glycans on Megakaryocytes to Regulate Platelet Count

Interferon-producing Siglec H-positive bone marrow immune cells engaged with O-glycan sialic acid moieties to regulate type I interferon secretion and platelet release, as evidenced by partially normalized platelet count following and inhibition of interferon and Siglec H receptors.