megakaryocytes

[Genome Biology] Using scRNA-Seq analysis of chimeric mouse embryos lacking the major erythroid regulator Gata1, scientists showed that genes with the step-changes in expression dynamics during erythroid differentiation failed to be upregulated in the mutant cells, thus underscoring the coordination of modulating transcription rate along a differentiation trajectory.

[Human Genomics] Scientists used the commercial Chromium platform to perform sc-ATAC-seq to measure chromatin accessibility in 11,611 single umbilical cord blood cells derived from one trisomy 18 syndrome patient and one healthy donor.

[Signal Transduction and Targeted Therapy] Aberrant bone marrow-M1/M2 MФ polarization, characterized by increased M1 MФs and decreased M2 MФs and accompanied by impaired megakaryopoiesis-supporting abilities, was found in patients with thrombocytopenia post-allotransplant.

[eLife] Researchers presented a miniaturized bone marrow tissue model that provided a screening bioreactor for personalized, pre-treatment response prediction to Eltrombopag for patients with thrombocytopenic disorders.

[Stem Cell Reports] Utilizing CRISPR-Cas9, researchers compared the in vitro phenotype of hematopoietic progenitor cells and megakaryocytes derived from induced pluripotent stem cell lines harboring mutations in either ETV6 or RUNX1.

[ACS Biomaterials Science & Engineering] Scientists fabricated coaxial extruded core–shell tubular scaffolds and extrusion-based bioprinted cell-laden mesh scaffolds to mimic the functional niche in vitro.