M2 Macrophages, but Not M1 Macrophages, Support Megakaryopoiesis by Upregulating PI3K-AKT Pathway Activity

Aberrant bone marrow-M1/M2 MФ polarization, characterized by increased M1 MФs and decreased M2 MФs and accompanied by impaired megakaryopoiesis-supporting abilities, was found in patients with thrombocytopenia post-allotransplant.