melanocytes

[Nature] The authors identified subsets of dermal fibroblasts that were responsible for driving patterned autoimmune activity, by using a robust mouse model of vitiligo that was based on the activation of endogenous auto-reactive CD8+ T cells that targeted epidermal melanocytes.

[Pediatric Blood & Cancer] Exposure to trametinib and azacitidine prevented development of trametinib resistance in NRAS-mutated human melanoma cells in vitro. Azacitidine acted synergistically with trametinib to inhibit the growth of trametinib-resistant melanoma cells.

[Oncogene] Investigators reported that matrix metalloproteinase 9 (MMP-9) localized to the nucleus of melanoma cells and potentiated gene expression by proteolytically clipping the histone H3 N-terminal tail.

[Cell Death & Disease] The authors identified the role of p32 in the malignancy of both murine and human melanoma and found that p32 knockdown led to reduced cell proliferation, migration, and invasion in murine and human melanoma cells.

[Cold Spring Harbor Perspectives in Biology] Investigators review diverse cellular interactions and highlight how far-reaching signals can be transmitted at the local level to enable skin stem cells to tailor their actions to suit the particular occasion and optimize fitness.

[Tissue Engineering Part C-Methods] Keratinocytes, fibroblasts, melanocytes, and mesenchymal stem cells (MSCs) are promising cell sources for cell spray procedures. Scientists focus on the different types of cells and spray instruments used in cell delivery procedures.