melanoma

[Biochemical Journal] Researchers showed that activation of apelin receptor (APLNR) upregulated IFN-γ signaling in melanoma cells through APLNR mediated β-arrestin 1 but not β-arrestin 2 recruitment.

[Communications Biology] By investigating the role of ARAF in NRAS-driven mouse melanoma through mass spectrometry experiments followed by a functional siRNA-based screen, scientists unexpectedly identified MITF as a direct ARAF partner.

[Cell Biochemistry and Biophysics] Scientists investigated the function of itraconazole-induced AMP-activated protein kinase alpha (AMPKα) in melanoma progression through ERK signaling.

[Translational Oncology] Silencing of TIM-3 shuttled by MV3 cells-derived exosomes improved CD4+ T cell immune function and inhibited macrophage M2 polarization to attenuate the growth and metastasis of melanoma cells.

[Cancer Cell International] Ebp1 expression was substantially higher in malignant melanoma (MM) than it was in normal skin, and Ebp1 was linked to the clinical stage and lymph node metastases of patients with MM.

[Current Opinion in Oncology] Scientists focus on new immunotherapeutic approaches studied in advanced melanoma previously treated by anti-programmed cell death 1 (PD-1) receptor or anti-cytolytic T-lymphocyte-associated protein 4 (CTLA-4) antibodies.