TGF-β-Mediated Epithelial–Mesenchymal Transition and Tumor-Promoting Effects in CMT64 Cells Are Reflected in the Transcriptomic Signature of Human Lung Adenocarcinoma

Scientists demonstrated for the first time that TGF-β could elicit epithelial–mesenchymal transition in a mouse lung adenocarcinoma cell line.
[Scientific Reports]
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Silencing Akt1 Enhances the Resistance of Prostate Cancer Cells to Starvation and Inhibits Starvation-Induced Lung Metastasis through Epithelial–Mesenchymal Transition in Prostate Cancer

Scientists reported that although silencing Akt1 enhanced the invasion of prostate cancer (PCa) cells induced by nutritional starvation (NST) in vitro, silencing Akt1 inhibited the PCa lung metastasis induced by NST in vivo.
[Medical Oncology]
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MicroRNA-200c/429 Mediated Regulation of Zeb1 Augments N-cadherin in Mouse Cardiac Mesenchymal Cells

Scientists investigated the expression of N-Cadherin, a trans-membrane protein that enhanced the cell adhesion and recently gained attention for differentiation and augmentation of stem cell function, in mouse cardiac MSCs.
[Cell Biology International]
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Bacterial Cancer Therapy of Autochthonous Colorectal Cancer Impacts Tumor Growth and Metabolic Landscape

Researchers aimed to better understand the tumor epithelium-targeted mechanisms of bacterial cancer therapy by using autochthonous mouse models of intestinal cancer and tumor organoid cultures to assess the effectiveness and consequences of oral treatment with aromatase A-deficient STm.
[JCI Insight]
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Heterogeneity of Subsets in Glioblastoma Mediated by Smad3 Palmitoylation

A mutation in isocitrate dehydrogenase 1 was found to suppress the transforming growth factor-beta signaling pathway and E2F4 interacted with Smad3 to inhibit expression of mesenchymal markers.
[Oncogenesis]
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Identification of a Novel Inhibitor of Liver Cancer Cell Invasion and Proliferation through Regulation of Akt and Twist1

Researchers investigated a novel compound, 3-acetyl-5,8-dichloro-2-((2,4-dichlorophenyl)amino)quinolin-4(1H)-one (ADQ), that showed significant suppression of wound healing and cellular invasion. This compound also inhibited anchorage-independent cell growth, multicellular tumor spheroid survival/invasion, and metalloprotease activities.
[Scientific Reports]
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CRYβB2 Enhances Tumorigenesis through Upregulation of Nucleolin in Triple Negative Breast Cancer

Researchers reported that the expression of CRYβB2 in breast cancer cells increased stemness, growth, and metastasis. Transcriptomics data revealed that CRYβB2 upregulated genes that were functionally associated with unfolded protein response, oxidative phosphorylation, and DNA repair, while down-regulating genes related to apoptosis.
[Oncogene]
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Progression of Melanoma Is Suppressed by Targeting All Transforming Growth Factor-β Isoforms with an FC Chimeric Receptor

Scientists revealed that TβRI‑TβRII‑Fc chimeric receptor suppressed the epithelial‑mesenchymal transition program in melanoma cells in vitro induced by any of the three TGF‑β isoforms, as revealed by decreased expression of mesenchymal markers.
[Oncology Reports]
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ZEB2 Facilitates Peritoneal Metastasis by Regulating the Invasiveness and Tumorigenesis of Cancer Stem-Like Cells in High-Grade Serous Ovarian Cancers

Investigators demonstrated that ZEB2, the transcription factor of epithelial–mesenchymal transition, was upregulated in ascites cells from high-grade serous ovarian cancer patients and in CD133+ cancer stem-like cells from epithelial ovarian cancer cell lines.
[Oncogene]
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Kras Activation in Endometrial Organoids Drives Cellular Transformation and Epithelial-Mesenchymal Transition

Investigators found that in KrasG12D-expressing endometrial organoids, Pten knockdown did not confer tumorigenicity, but Cdkn2a knockdown or Trp53 deletion led to the development of carcinosarcoma, a rare, aggressive tumor comprising both carcinoma and sarcoma.
[Oncogenesis]
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ENO1 Promotes Lung Cancer Metastasis via HGFR and WNT Signaling-Driven Epithelial-Mesenchymal Transition

Reserachers found that high expression of α-enolase was present in metastatic lung cancer cell lines and malignant tumors and was associated with poor overall survival of lung cancer patients.
[Cancer Research]
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