Based on the analysis of RNA-sequencing data, investigators identified a fusion transcript of CD63–breast cancer anti-oestrogen-resistance 4 (BCAR4) in a Korean patient with lung adenocarcinoma who did not harbour any known activating mutations in EGFR and KRAS genes. To investigate the oncogenic effect of CD63–BCAR4, in vitro and in vivo animal experiments were performed.
[British Journal of Cancer]
6606345 ILB34EQJ items 1 apa default asc 1
Bae, K., Kim, J. H., Jung, H., Kong, S.-Y., Kim, Y.-H., Kim, S., Lee, G. K., Lee, J. S., Lee, J. J.-K., Ju, Y. S., Choi, Y.-K., & Yoon, K.-A. (2020). A fusion of CD63–BCAR4 identified in lung adenocarcinoma promotes tumorigenicity and metastasis. British Journal of Cancer, 1–9. https://doi.org/10.1038/s41416-020-01146-3 Cite
The authors investigated the occurrence of epithelial–mesenchymal transition (EMT) in airways native tissue, primary cells and cell lines expressing mutant cystic fibrosis transmembrane conductance regulator through the expression of epithelial and mesenchymal markers as well as EMT-associated transcription factors.
[Cell Death & Disease]
1254621 3DE4JUJT items 1 apa default asc 1
Scientists triggered partial epithelial-to-mesenchymal transition or unjamming transition in differentiated primary human bronchial epithelial cells.
1254621 BFUJ5CN6 items 1 apa default asc 1
The authors present a new protocol based on surface enhanced resonance Raman scattering (SERRS) gold multivalent nanostructures to identify and enumerate tumor cells with epithelial and mesenchymal markers.
6630899 7UULLVCH items 1 apa default asc 1
Litti, L., Colusso, A., Pinto, M., Ruli, E., Scarsi, A., Ventura, L., Toffoli, G., Colombatti, M., Fracasso, G., & Meneghetti, M. (2020). SERRS multiplexing with multivalent nanostructures for the identification and enumeration of epithelial and mesenchymal cells. Scientific Reports, 10(1), 15805. https://doi.org/10.1038/s41598-020-72911-w Cite
Scientists found that Methyl-CpG-binding protein 2 was upregulated in pancreatic cancer tissues, enhanced migration, invasion, and proliferation in pancreatic cancer cells, and promoted tumorigenesis.
6630899 5HNBTFC3 items 1 apa default asc 1
Wang, H., Li, J., He, J., Liu, Y., Feng, W., Zhou, H., Zhou, M., Wei, H., Lu, Y., Peng, W., Du, F., Gong, A., & Xu, M. (2020). Methyl-CpG-binding protein 2 drives the Furin/TGF-β1/Smad axis to promote epithelial–mesenchymal transition in pancreatic cancer cells. Oncogenesis, 9(8), 1–14. https://doi.org/10.1038/s41389-020-00258-y Cite
Investigators described for the first time the impact of adipose-derived stem cells over the malignant behavior of cervical cancer cells.
6445218 FFKX6LKG items 1 apa default asc 1
Castro-Oropeza, R., Vazquez-Santillan, K., Díaz-Gastelum, C., Melendez-Zajgla, J., Zampedri, C., Ferat-Osorio, E., Rodríguez-González, A., Arriaga-Pizano, L., & Maldonado, V. (2020). Adipose-derived mesenchymal stem cells promote the malignant phenotype of cervical cancer. Scientific Reports, 10(1), 14205. https://doi.org/10.1038/s41598-020-69907-x Cite
Researchers evaluated the inhibitory effect of a tyrosine kinase inhibitor sunitinib and the integrin-αⅤβ3 targeted cyclic peptide (cRGDfK) on EMT in human lung cancer cells.
1254621 HIX7K7LG items 1 apa default asc 1
Human alveolar epithelial A549 cells were cultured for 24 hours in conditioned media of THP-1 monocyte-derived macrophages with 1–20 μM aesculetin.
[International Journal of Molecular Sciences]
1254621 SMTGZLHX items 1 apa default asc 1
Scientists explored the expressions of cell phenotype markers and differentiation regulators in isolated type II alveolar epithelial stem cells (AEC II) to analyze the correlation between GSK‐3β/TGF‐β1/β‐catenin signaling pathway, lin28/let‐7 balance, and AEC II phenotypes at different injury phases following irradiation.
1254621 HZR4PBRG items 1 apa default asc 1