Triptolide Suppresses the Growth and Metastasis of Non-small Cell Lung Cancer by Inhibiting β-Catenin-Mediated Epithelial–Mesenchymal Transition

Researchers investigated the effect of triptolide on the migration and invasion of non-small cell lung cancer cell lines.
[Acta Pharmacologica Sinica]
Deng, Q., Lei, X., Zhong, Y., Chen, M., Ke, Y., Li, Z., Chen, J., Huang, L., Zhang, Y., Liang, L., Lin, Z., Liu, Q., Li, S., & Yu, X. (2021). Triptolide suppresses the growth and metastasis of non-small cell lung cancer by inhibiting β-catenin-mediated epithelial–mesenchymal transition. Acta Pharmacologica Sinica, 1–12. https://doi.org/10.1038/s41401-021-00657-w Cite
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Electrospun Nanofiber Scaffolds for the Propagation and Analysis of Breast Cancer Stem Cells In Vitro

The authors developed a 3D culture platform that mimics the metastatic tumor extracellular matrix to effectively increase cancer stem cell (CSC) population in vitro and allow CSC analysis.
[Biomedical Materials]
Prieto, E. I., Mojares, E. B. A., Cortez, J. J. M., & Jr, M. R. V. (2021). Electrospun nanofiber scaffolds for the propagation and analysis of breast cancer stem cells in vitro. Biomedical Materials, 16(3), 035004. https://doi.org/10.1088/1748-605x/abc3dd Cite
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Interplay between Tumor Microenvironment and Partial EMT as the Driver of Tumor Progression

The authors focus on important role of tumor-intrinsic factors and tumor microenvironment in driving pEMT and emphasize that engineered controlled microenvironments are instrumental to provide mechanistic insights into pEMT biology.
[iScience]

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Tumor-Suppressor Function of Beclin 1 in Breast Cancer Cells Requires E-Cadherin

Researchers performed a genome-wide CRISPR/Cas9 screen in MCF7 breast cancer cells to identify genes whose loss of function reversed Beclin 1-dependent inhibition of cellular proliferation.
[Proceedings of the National Academy of Sciences of the United States of America]
Wijshake, T., Zou, Z., Chen, B., Zhong, L., Xiao, G., Xie, Y., Doench, J. G., Bennett, L., & Levine, B. (2021). Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin. Proceedings of the National Academy of Sciences, 118(5). https://doi.org/10.1073/pnas.2020478118 Cite
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Dasatinib Induces Endothelial-to-Mesenchymal Transition in Human Vascular-Endothelial Cells: Counteracted by Cotreatment with Bosutinib

The authors investigated the effects of tyrosine kinase inhibitors (TKIs) on the development of endothelial-to-mesenchymal transition in human vascular-endothelial cells (VECs). Exposure of VECs to dasatinib, but not to other TKIs, produced a significant increase in the formation of spindle-shaped cells.
[International Journal of Hematology]
Alkebsi, L., Wang, X., Ohkawara, H., Fukatsu, M., Mori, H., & Ikezoe, T. (2021). Dasatinib induces endothelial-to-mesenchymal transition in human vascular-endothelial cells: counteracted by cotreatment with bosutinib. International Journal of Hematology. https://doi.org/10.1007/s12185-020-03034-1 Cite
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A Fusion of CD63–BCAR4 Identified in Lung Adenocarcinoma Promotes Tumorigenicity and Metastasis

Based on the analysis of RNA-sequencing data, investigators identified a fusion transcript of CD63–breast cancer anti-oestrogen-resistance 4 (BCAR4) in a Korean patient with lung adenocarcinoma who did not harbour any known activating mutations in EGFR and KRAS genes. To investigate the oncogenic effect of CD63–BCAR4, in vitro and in vivo animal experiments were performed.
[British Journal of Cancer]
Bae, K., Kim, J. H., Jung, H., Kong, S.-Y., Kim, Y.-H., Kim, S., Lee, G. K., Lee, J. S., Lee, J. J.-K., Ju, Y. S., Choi, Y.-K., & Yoon, K.-A. (2020). A fusion of CD63–BCAR4 identified in lung adenocarcinoma promotes tumorigenicity and metastasis. British Journal of Cancer, 1–9. https://doi.org/10.1038/s41416-020-01146-3 Cite
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Mutant CFTR Drives TWIST1 Mediated Epithelial–Mesenchymal Transition

The authors investigated the occurrence of epithelial–mesenchymal transition (EMT) in airways native tissue, primary cells and cell lines expressing mutant cystic fibrosis transmembrane conductance regulator through the expression of epithelial and mesenchymal markers as well as EMT-associated transcription factors.
[Cell Death & Disease]
Quaresma, M. C., Pankonien, I., Clarke, L. A., Sousa, L. S., Silva, I. A. L., Railean, V., Doušová, T., Fuxe, J., & Amaral, M. D. (2020). Mutant CFTR Drives TWIST1 mediated epithelial–mesenchymal transition. Cell Death & Disease, 11(10), 1–18. https://doi.org/10.1038/s41419-020-03119-z Cite
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In Primary Airway Epithelial Cells, the Unjamming Transition Is Distinct from the Epithelial-to-Mesenchymal Transition

Scientists triggered partial epithelial-to-mesenchymal transition or unjamming transition in differentiated primary human bronchial epithelial cells.
[Nature Communications]
Mitchel, J. A., Das, A., O’Sullivan, M. J., Stancil, I. T., DeCamp, S. J., Koehler, S., Ocaña, O. H., Butler, J. P., Fredberg, J. J., Nieto, M. A., Bi, D., & Park, J.-A. (2020). In primary airway epithelial cells, the unjamming transition is distinct from the epithelial-to-mesenchymal transition. Nature Communications, 11(1), 5053. https://doi.org/10.1038/s41467-020-18841-7 Cite
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SERRS Multiplexing with Multivalent Nanostructures for the Identification and Enumeration of Epithelial and Mesenchymal Cells

The authors present a new protocol based on surface enhanced resonance Raman scattering (SERRS) gold multivalent nanostructures to identify and enumerate tumor cells with epithelial and mesenchymal markers.
[Scientific Reports]

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Methyl-CpG-Binding Protein 2 Drives the Furin/Tgf-β1/Smad Axis to Promote Epithelial-Mesenchymal Transition in Pancreatic Cancer Cells

Scientists found that Methyl-CpG-binding protein 2 was upregulated in pancreatic cancer tissues, enhanced migration, invasion, and proliferation in pancreatic cancer cells, and promoted tumorigenesis.
[Oncogenesis]

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Adipose-Derived Mesenchymal Stem Cells Promote the Malignant Phenotype of Cervical Cancer

Investigators described for the first time the impact of adipose-derived stem cells over the malignant behavior of cervical cancer cells.
[Scientific Reports]
Castro-Oropeza, R., Vazquez-Santillan, K., Díaz-Gastelum, C., Melendez-Zajgla, J., Zampedri, C., Ferat-Osorio, E., Rodríguez-González, A., Arriaga-Pizano, L., & Maldonado, V. (2020). Adipose-derived mesenchymal stem cells promote the malignant phenotype of cervical cancer. Scientific Reports, 10(1), 14205. https://doi.org/10.1038/s41598-020-69907-x Cite
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