A Fusion of CD63–BCAR4 Identified in Lung Adenocarcinoma Promotes Tumorigenicity and Metastasis

Based on the analysis of RNA-sequencing data, investigators identified a fusion transcript of CD63–breast cancer anti-oestrogen-resistance 4 (BCAR4) in a Korean patient with lung adenocarcinoma who did not harbour any known activating mutations in EGFR and KRAS genes. To investigate the oncogenic effect of CD63–BCAR4, in vitro and in vivo animal experiments were performed.
[British Journal of Cancer]
Bae, K., Kim, J. H., Jung, H., Kong, S.-Y., Kim, Y.-H., Kim, S., Lee, G. K., Lee, J. S., Lee, J. J.-K., Ju, Y. S., Choi, Y.-K., & Yoon, K.-A. (2020). A fusion of CD63–BCAR4 identified in lung adenocarcinoma promotes tumorigenicity and metastasis. British Journal of Cancer, 1–9. https://doi.org/10.1038/s41416-020-01146-3 Cite
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Mutant CFTR Drives TWIST1 Mediated Epithelial–Mesenchymal Transition

The authors investigated the occurrence of epithelial–mesenchymal transition (EMT) in airways native tissue, primary cells and cell lines expressing mutant cystic fibrosis transmembrane conductance regulator through the expression of epithelial and mesenchymal markers as well as EMT-associated transcription factors.
[Cell Death & Disease]
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In Primary Airway Epithelial Cells, the Unjamming Transition Is Distinct from the Epithelial-to-Mesenchymal Transition

Scientists triggered partial epithelial-to-mesenchymal transition or unjamming transition in differentiated primary human bronchial epithelial cells.
[Nature Communications]
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SERRS Multiplexing with Multivalent Nanostructures for the Identification and Enumeration of Epithelial and Mesenchymal Cells

The authors present a new protocol based on surface enhanced resonance Raman scattering (SERRS) gold multivalent nanostructures to identify and enumerate tumor cells with epithelial and mesenchymal markers.
[Scientific Reports]
Litti, L., Colusso, A., Pinto, M., Ruli, E., Scarsi, A., Ventura, L., Toffoli, G., Colombatti, M., Fracasso, G., & Meneghetti, M. (2020). SERRS multiplexing with multivalent nanostructures for the identification and enumeration of epithelial and mesenchymal cells. Scientific Reports, 10(1), 15805. https://doi.org/10.1038/s41598-020-72911-w Cite
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Methyl-CpG-Binding Protein 2 Drives the Furin/Tgf-β1/Smad Axis to Promote Epithelial-Mesenchymal Transition in Pancreatic Cancer Cells

Scientists found that Methyl-CpG-binding protein 2 was upregulated in pancreatic cancer tissues, enhanced migration, invasion, and proliferation in pancreatic cancer cells, and promoted tumorigenesis.
[Oncogenesis]
Wang, H., Li, J., He, J., Liu, Y., Feng, W., Zhou, H., Zhou, M., Wei, H., Lu, Y., Peng, W., Du, F., Gong, A., & Xu, M. (2020). Methyl-CpG-binding protein 2 drives the Furin/TGF-β1/Smad axis to promote epithelial–mesenchymal transition in pancreatic cancer cells. Oncogenesis, 9(8), 1–14. https://doi.org/10.1038/s41389-020-00258-y Cite
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Adipose-Derived Mesenchymal Stem Cells Promote the Malignant Phenotype of Cervical Cancer

Investigators described for the first time the impact of adipose-derived stem cells over the malignant behavior of cervical cancer cells.
[Scientific Reports]
Castro-Oropeza, R., Vazquez-Santillan, K., Díaz-Gastelum, C., Melendez-Zajgla, J., Zampedri, C., Ferat-Osorio, E., Rodríguez-González, A., Arriaga-Pizano, L., & Maldonado, V. (2020). Adipose-derived mesenchymal stem cells promote the malignant phenotype of cervical cancer. Scientific Reports, 10(1), 14205. https://doi.org/10.1038/s41598-020-69907-x Cite
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Cyclic Pentapeptide cRGDfK Enhances the Inhibitory Effect of Sunitinib on TGF-β1-Induced Epithelial-to-Mesenchymal Transition in Human Non-Small Cell Lung Cancer Cells

Researchers evaluated the inhibitory effect of a tyrosine kinase inhibitor sunitinib and the integrin-αβ3 targeted cyclic peptide (cRGDfK) on EMT in human lung cancer cells.
[PLoS One]
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Aesculetin Attenuates Alveolar Injury and Fibrosis Induced by Close Contact of Alveolar Epithelial Cells with Blood-Derived Macrophages via IL-8 Signaling

Human alveolar epithelial A549 cells were cultured for 24 hours in conditioned media of THP-1 monocyte-derived macrophages with 1–20 μM aesculetin.
[International Journal of Molecular Sciences]
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Glycogen Synthase Kinase‐3β Promotes Radiation‐Induced Lung Fibrosis by Regulating β‐Catenin/lin28 Signaling Network to Determine Type II Alveolar Stem Cell Transdifferentiation State

Scientists explored the expressions of cell phenotype markers and differentiation regulators in isolated type II alveolar epithelial stem cells (AEC II) to analyze the correlation between GSK‐3β/TGF‐β1/β‐catenin signaling pathway, lin28/let‐7 balance, and AEC II phenotypes at different injury phases following irradiation.
[FASEB Journal]
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