mesenchymal stem cells

[Gene Therapy] Researchers elucidated that exosomal miR-133b-3p from bone marrow MSCs suppressed angiogenesis and oxidative stress in diabetic retinopathy via FBN1 repression.

[Scientific Reports] Scientists compared the neurogenic ability of dental pulp stem cells to bone marrow-derived MSCs under inflammatory stimulation.

[Cell Death Discovery] To improve the effectiveness of naïve hair follicle-derived-MSC (HF-MSC) treatments on liver cirrhosis (LC), the authors used bioinformatic tools to identify an exogenous gene targeting hepatic stellate cells (HSCs) among the differentially expressed genes in LC to modify HF-MSCs.

[Stem Cell Reviews and Reports] The authors summarize the types of MSCs that could be potentially applied in regenerative dentistry, the possible molecular cargos of MSC-extracellular vesicles (EVs), and the major effects of MSC-EVs on the therapeutic induction of osteogenic differentiation.

[Stem Cell Research & Therapy] Scientists summarize the clinical efficacy of MSCs in the treatment of COVID-19 based on published results, including mortality, time to symptom improvement, computed tomography imaging, cytokines, and safety, while elaborating on the possible mechanisms underpinning the effects of MSCs, to provide a reference for subsequent studies.

[BioRestorative Therapies, Inc. (Globe Newswire, Inc.)] BioRestorative Therapies, Inc. announced that it has initiated the site selection process for its active Phase II clinical trial targeting chronic lumbar disc disease with BRTX-100, a product formulated from autologous cultured MSCs collected from the patient’s bone marrow.