mesenchymal stem cells

[Experimental and Molecular Medicine] Scientists investigated the role of microbiota-derived lactate in hematopoiesis using mice deficient in G-protein-coupled receptor (Gpr) 81 (Gpr81−/−), an established lactate receptor. They detected significant depletion of total HSCs in the bone marrow of Gpr81−/− mice compared with heterogenic mice in a steady state.

[Spinal Cord] Three individuals with the traumatic spinal cord injury of the thoracic level were enrolled. They received the autologous olfactory ensheathing cell and MSC combination through the lumbar puncture.

[Blood Advances] The pathophysiology of poor graft function can be conceptualized as dysfunction related to the number or productivity of the stem cell compartment, defects in bone marrow microenvironment components such as mesenchymal stromal cells and endothelial cells, or immunological suppression of post allogeneic stem cell transplant hematopoiesis.

[Signal Transduction and Targeted Therapy] Investigators summarize the recent progress in MSC therapy for COVID-19 and highlight the challenges in the field.

[NPJ Regenerative Medicine] Researchers found that cerebrospinal fluid pulsation stress—cyclic pulsation stress—could promote the osteogenic and angiogenic abilities of rat MSCs, thereby promoting tissue-engineered laminae’s bone and blood vessel formation.

[Journal of Nanobiotechnology] A thermosensitive acellular extracellular matrix hydrogel coupled with adipose-derived mesenchymal stem cell (ADSC) exosomes that inherited the superior properties of nucleus pulposus tissue and ADSCs was fabricated to ameliorate intervertebral disc degeneration.