mesenchymal stem cells

[Experimental & Molecular Medicine] Scientists showed that bone marrow-derived MSCs contributed to fibrosis in myeloproliferative neoplasms by differentiating into αSMA-positive myofibroblasts.

[Cell Death Discovery] Proliferation capability, osteogenic lineage commitment, senescence-associated secreted phenotype and circadian oscillation of clock genes under osteogenic condition were assessed in bone marrow MSCs from young adult and aged adult mice.

[iScience] Engineered 3D tuneable biomimetic scaffolds were used to control the cell microenvironment of adipose-derived MSCs, which exhibited a collagen density-specific profile for early and late stage bone cell lineage status.

[iScience] Compared to using MSCs or rh-ACE2 alone, the administration of ACE2-MSCs much more significantly reduced inflammatory factors and pyroptosis factors and alleviated lung injury in vivo and in vitro, which might have been due to the increased activities of secretory ACE2.

[American Journal of Respiratory and Critical Care Medicine] Researchers investigated whether a multifactorial neonatal mouse model of lung injury perturbed neural progenitor cell function and assessed the ability of human umbilical cord-derived MSC extracellular vesicles to mitigate pulmonary and neurologic injury.

[Nanomedicine] Investigators explored the effect of small extracellular vesicles from induced pluripotent stem cell-derived MSCs on acute pain and investigated the underlying mechanisms.