ACE2 Overexpressing Mesenchymal Stem Cells Alleviates COVID-19 Lung Injury by Inhibiting Pyroptosis

Compared to using MSCs or rh-ACE2 alone, the administration of ACE2-MSCs much more significantly reduced inflammatory factors and pyroptosis factors and alleviated lung injury in vivo and in vitro, which might have been due to the increased activities of secretory ACE2.