monocytes

[Communications Biology] Scientists showed how people living with HIV-1 (PLWH) who naturally control the virus had a reduced proportion of CD4+CCR6+ and CD8+CCR6+ cells compared to PLWH on suppressive antiretroviral therapy and HIV-1 negative controls.

[Circulation Research] Genetic deletion of pyruvate kinase muscle 2 (PKM2) in myeloid cells or limiting its nuclear translocation reduced atherosclerosis by suppressing inflammation and enhancing efferocytosis.

[Nature Communications] Utilizing single-cell RNA and T cell receptor profiling, researchers showed that irrespective of STAT3 mutation status, T cell large granular lymphocytic leukemia clonotypes were more cytotoxic and exhausted than healthy reactive clonotypes.

[Journal of Experimental Medicine] Investigators showed that monocytes acquired macrophage markers upon glomerulonephritis and may have been derived from CCR2+CX3CR1+ double-positive monocytes, which were preferentially recruited, dwelled within glomerular capillaries, and acquired proinflammatory characteristics in the nephritic kidney.

[Circulation Research] Genetic deletion of pyruvate kinase muscle 2 (PKM2) in myeloid cells or limiting its nuclear translocation reduced atherosclerosis by suppressing inflammation and enhancing efferocytosis.

[Nature Communications] Utilizing single-cell RNA and T cell receptor profiling, researchers showed that irrespective of STAT3 mutation status, T cell large granular lymphocytic leukemia clonotypes were more cytotoxic and exhausted than healthy reactive clonotypes.