monocytes

[Acta Pharmacologica Sinica] Scientists demonstrated that GPR84 was highly upregulated in inflamed colon tissues of active ulcerative colitis patients and dextran sulfate sodium-induced colitis mice.

[Nature Communications] Researchers showed, using spinning-disk confocal microscopy, that large F4/80hiGATA6+ peritoneal cavity macrophages promptly accumulate at damaged intestinal sites upon intestinal thermal injury and upon dextran sodium sulfate induced colitis in mice via a direct route from the peritoneal cavity.

[British Journal of Pharmacology] Investigators explored the role of BTK on the migration of myeloid cells; in vitro using chemotaxis assays and in vivo using zymosan induced peritonitis as model systems.

[Redox Biology] Researchers reported that β-glucan-trained macrophages from mice harboring a myeloid-specific deletion of the catalytic subunit of glutamate-cysteine ligase showed impaired GSH synthesis and decreased proinflammatory cytokine production in response to lipopolysaccharide challenge.

[Journal of Clinical Investigation] Investigators found that BMP9/BMP10-ALK1 signaling controlled the identity and self-renewal of Kupffer cells through a Smad4-dependent pathway.

[Basic Research in Cardiology] A Total of 20 immune cell subtypes were identified among 46,040 cells. The function of immune cells in acute rejection were illustrated simultaneously.