multiple sclerosis

[ACS Biomaterials Science & Engineering] Investigators showed that interleukin-13 packaged in extra-large-pore mesoporous silica nanoparticles was protected from degradation and directs the alternative activation of macrophages both in vitro and in vivo.

[Proceedings of the National Academy of Sciences of the United States of America] The authors visualized central nervous system inflammatory processes in models of multiple sclerosis (MS) live in vivo and in MS brains and discovered that central nervous system-infiltrating T helper 17 cells form prolonged stable contact with oligodendrocytes.

[Biochemical and Biophysical Research Communications] The authors evaluated the effects of the autophagy activator AZD8055 on experimental autoimmune encephalomyelitis (EAE). EAE model mice were established, histological examination was performed to assess the degree of inflammatory cell infiltration and demyelination.

[Proceedings of the National Academy of Sciences of the United States of America] In vitro studies demonstrated that IFP35 and NMI were released by multiple cells. IFP35 and NMI subsequently triggered nuclear factor kappa B–dependent activation of microglia via the TLR4 pathway.

[Stem Cell Research] Scientists generated an induced pluripotent stem cells (iPSC) line from bone marrow-MSCs employing a non-integrating episomal vector. The generated iPSCs expressed pluripotency markers, showed a normal karyotype, and exhibited the potential for in vitro differentiation into three germ layers.

[Cellular & Molecular Immunology] Using transcriptome microarray analysis at different stages of experimental autoimmune encephalomyelitis (EAE), scientists identified the EAE progression-related circINPP4B, which showed upregulated expression in Th17 cells from mice with EAE and during Th17 differentiation in vitro.