multiple sclerosis

[Hope Biosciences Stem Cell Research Foundation (BusinessWire, Inc.)] Non-profit research organization Hope Biosciences Stem Cell Research Foundation has received FDA authorization for a randomized, double-blind, single center, Phase II clinical trial to assess the efficacy of multiple intravenous infusions of autologous adipose-derived mesenchymal stem cells in improving symptoms and quality of life in patients with mild-to-moderate multiple sclerosis.

[Journal of Experimental Medicine] Scientists review the interactions between immune cells and astrocytes and their roles in health and neurological diseases, with a special focus on multiple sclerosis.

[Cell Reports] Using a model of dermal inflammation, investigators demonstrated that SPNS2 supplies the S1P that guided T cells out of lymph nodes with an ongoing immune response.

[Scientific Reports] Scientists used a RiboTag strategy to characterize ribosome-bound mRNA only in microglia without incurring possible transcriptional changes after cell isolation.

[Cell Death Discovery] There is no report on the expression pattern and potential mechanism of Syncytin-1 in hepatocellular carcinoma (HCC). Functional experiments in vitro and in vivo demonstrated that Syncytin-1 enhanced cell proliferation, metastasis, and tumorigenicity in HCC.

[European Journal of Immunology] Researchers reported a direct comparison of E2- and P4-mediated effects on human CD4+ T cells, key cells in immune regulation. T cells were stimulated to obtain different levels of activation and exposed to a broad range of hormone concentrations.