muscle cells

[Scientific Reports] The authors investigated the potential benefit of LCZ696, an angiotensin receptor–neprilysin inhibitor against doxorubicin-induced cardiotoxicity in rats and H9c2 cells and determined whether the mechanism underlying any such effects involved its antioxidant activity.

[Nature Communications] Treatment of Chkb−/− myocytes with peroxisome proliferator-activated receptor agonists enabled fatty acids to be used for β-oxidation and prevented triacyglyerol accumulation, while simultaneously increasing expression of the compensatory choline kinase alpha isoform, preventing muscle cell injury.

[Cell Stem Cell] Researchers induced efficient human pluripotent stem-cell-derived cardiomyocytes maturation through metabolic-pathway modulations and found that peroxisome-proliferator-associated receptor (PPAR) signaling regulated glycolysis and fatty acid oxidation in an isoform-specific manner.

[Scientific Reports] Investigators prepared mitochondria-activated stem cells (MITO cells) for use in transplantation. MITO cells, which were cardiac progenitor cells activated by the mitochondrial delivery of resveratrol with an anti-oxidant and mitochondrial activation effects, were successfully prepared using a mitochondrial targeting nanocarrier.

[Nature Communications] Pannexin-1 on endothelial cells acted as a conduit for ATP release that stimulated macrophage activation via P2X7 receptors and mitochondrial DNA release to increase IL-1β and HMGB1 secretion.

[ACS Nano] Scientists fabricated a micro- to nanoscale network assembly consisting of copper ion and epigallocatechin gallate via π–π interactions, metal coordination, and oxidative polymerization.